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| ISOSORBIDE 5-MONONITRATE | ||
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PRODUCT IDENTIFICATION |
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| CAS NO. | 16051-77-7 |
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| EINECS NO. | 240-197-2 | |
| FORMULA | C6H9NO6 | |
| MOL WT. | 191.14 | |
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H.S. CODE |
3003.90 |
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TOXICITY |
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| SYNONYMS | 1,4:3,6-Dianhydro-D-glucitol 5-mononitrate; | |
| Mononitrato de isosorbida; Mononitrate d'isosorbide; 5-Isosorbide mononitrate; | ||
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CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE | white crystalline powder | |
| MELTING POINT | 88 - 91 C | |
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| SPECIFIC GRAVITY |
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| SOLUBILITY IN WATER | ||
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AUTOIGNITION |
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NFPA RATINGS |
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REFRACTIVE INDEX |
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| FLASH POINT |
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| STABILITY | Stable under ordinary conditions. Hygroscopic. | |
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APPLICATIONS |
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| Isosorbide is a bicyclic ether derivative of glucitol. The nitric acid esters of isosorbide are used as osmotic diuretic to reduce intraocular pressure with effects on both arteries and veins and to treat coronary insufficiency and angina pectoris. The monoester is a white crystalline powder; melting point 140 C; freely soluble in water, alcohol and chloroform. The diester is a white crystalline powder; melting point 70 C; sparingly soluble in water; soluble in organic solvents (acetone, alcohol, ether); administered sublingually and orally. Diester is a explosive. It should be diluted (25 - 40%) with lactose or mannitol for transportation. Chemical designation is 1,4:3,6-dianhydro-D-glucitol mono (di) nitrate. | ||
| SALES SPECIFICATION (USP) | ||
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APPEARANCE |
white crystalline powder | |
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PURITY |
98.0% min (Lactose 70 - 80%) |
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| MELTING POINT |
88 - 91 C |
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SULFATED ASH |
0.1% max |
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HEAVY METALS |
20ppm max |
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| TRANSPORTATION | ||
| PACKING | 25kgs
in Drum | |
| HAZARD CLASS | 4.1 (Packing Group: II) | |
| UN NO. | 2907 | |
| OTHER INFORMATION | ||
| Hazard Symbols: XN, Risk Phrases: 5-22, Safety Phrases: 36 | ||
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